IL-12 R beta 2 / APC / REA333
Product Details
| Description | Clone REA333 recognizes the human interleukin 12 (IL-12) receptor subunit beta-2 (IL-12R beta2) antigen, a single-pass type I membrane protein which forms the functional high affinity IL-12 receptor together with the IL-12R beta1 subunit. While the IL-12R beta1 subunit is constitutively expressed, the expression of the IL-12R beta2 gene is up-regulated by interferon gamma. IL-12R beta2 is expressed by Tʜ1 cells and IL-12 signaling through the IL-12 receptor leads to the phosphorylation of STAT4 and continued Tʜ1 differentiation. The IL-12R beta2 subunit plays an important role in Tʜ1 cell differentiation, since its absence leads to an abortive Tʜ1 differentiation that has dysfunctional production of Tʜ1 effector molecules. The up-regulation of IL-12R beta2 is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. | Additional information: Clone REA333 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA333 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About IL-12 R beta 2
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
The protein encoded by this gene is a type I transmembrane protein identified as a subunit of the interleukin 12 receptor complex. The coexpression of this and IL12RB1 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The expression of this gene is up-regulated by interferon gamma in Th1 cells, and plays a role in Th1 cell differentiation. The up-regulation of this gene is found to be associated with a number of infectious diseases, such as Crohn's disease and leprosy, which is thought to contribute to the inflammatory response and host defense. Several transcript variants encoding different isoforms and non-protein coding transcripts have been found for this gene. [provided by RefSeq, Apr 2012]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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