Fetal Hemoglobin / APC / REA533

Product Details
Description Clone REA533 recognizes the human fetal hemoglobin (HbF) antigen, a form of hemoglobin present during fetal development. The hemoglobin molecule is a tetramer composed of two subunits of alpha-like globin peptide chains and two subunits of the beta-like globin peptides, along with heme moieties necessary for this moleculeĀ“s oxygen-carrying capacity. When production of the first enucleated definitive erythrocytes commences from stem and progenitor cells in the fetal liver, the predominant beta-like globin molecule produced is gamma-globin. The gamma-globin chains combine with adult alpha-globin chains into a stable tetramer forming HbF. Shortly after the time of birth there is a switch from predominant expression of HbF to adult hemoglobin (HbA), which is mediated by a transcriptional switch in definitive erythroid progenitors from gamma- to beta-globin. The synthesis of HbF is normally reduced to very low levels of less than 0.6% of the total hemoglobin in adults. HbF levels may be increased in adults in a number of inherited and acquired disorders. The clinical significance of these conditions with raised HbF relates to their interaction in disorders such as sickle cell disease and beta-thalassemia in which raised levels of HbF can lead to considerable amelioration of disease severity. | Additional information: Clone REA533 displays negligible binding to Fc receptors.
Conjugate APC
Clone REA533
Target Species Human
Applications FC
Supplier Miltenyi Biotec
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Experiment Design Tools
Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Additional
Sources
Reviews & Ratings
Looking for more options?

17 Fetal Hemoglobin antibodies from over 3 suppliers available with over 7 conjugates.

Supplier Page
 Compare