About CD27
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. This receptor transduces signals that lead to the activation of NF-kappaB and MAPK8/JNK. Adaptor proteins TRAF2 and TRAF5 have been shown to mediate the signaling process of this receptor. CD27-binding protein (SIVA), a proapoptotic protein, can bind to this receptor and is thought to play an important role in the apoptosis induced by this receptor. [provided by RefSeq, Jul 2008]

About Spark NIR 685
Spark NIR® 685 from Biolegend is a fluorophore designed for spectral flow cytometry with an excitation peak at 633 nm and an emission peak at 685 nm. This fluorophore is an alternative to Alexa Fluor™ 660 and can be efficiently excited by the 633 nm laser and can be unmixed from Alexa Fluor™ 647 and Alexa Fluor™ 700.