E-Selectin / APC / REA369
Product Details
| Description | Clone REA369 recognizes the mouse CD62E antigen, a single-pass type I membrane glycoprotein also known as E-selectin. CD62E is expressed on endothelial cells and plays a critical role in the recruitment of the appropriate blood cell into specific local sites. It mediates the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with P-selectin glycoprotein ligand 1, which promotes slow rolling and adhesion. CD62E is transcriptionally induced in response to inflammatory cytokines, such as IL-1beta and TNFalpha. It has an important role during hematopoietic stem/progenitor cell trafficking to the bone marrow, and for the maintenance of their quiescent phenotype in vivo. Because selectins are also constitutively expressed in the endothelium of certain tissues such as bone marrow even in the absence of inflammatory stimulation, there has been a growing appreciation that these receptors may be important for tissue homeostasis. Elevated cellular levels of CD62E have been documented in various diseases associated with a pro-inflammatory condition, including diabetes, atherosclerosis, rheumatoid arthritis, and cancer. Conversely, therapeutic strategies, which reduce vascular injury, result in significant down-regulation of CD62E gene expression. | Additional information: Clone REA369 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA369 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About E-Selectin
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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