HACE1 / Biotin / Monoclonal

Product Details

Description	HACE1 Monoclonal Antibody, Biotin conjugate. E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.IP 0.5 mg/ml
Conjugate	Biotin
Clone	Monoclonal
Target Species	Human
Applications	IP
Supplier	Thermo Fisher Scientific
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