CD8 / Pacific Green / 3B5

Product Details

Description	CD8 Monoclonal Antibody, Pacific Green™ conjugate (3B5). CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35 % of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells. CD38 (T10) is a single chain 46 kDa type II integral glycoprotein with a short N terminal cytoplasmic tail. CD38 is highly expressed on thymocytes. It is also expressed by early cells of B and T lineages, NK cells, plasma cells, monocytes and macrophages and may be detected on cells from multiple myeloma, ALL (B and T) and some AML. In normal lymph nodes and tonsils the antigen is detected mainly on B cells in germinal centers and in plasma cells. The extracellular domain of the molecule shares a high homology sequence with Aplysia ADP ribosyl cyclase. CD38 functions as a multicatalytic ectoenzyme serving as ADP ribosyl cyclase, ADPR hydrolase and possibly NAD+ glycohydrolase, or as a surface receptor.FACS Assay Dependent
Conjugate	Pacific Green
Clone	3B5
Target Species	Human
Applications	FC
Supplier	Thermo Fisher Scientific
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About Pacific Green
Pacific Green® (Pac Green, PacGreen) is an green-emitting organic fluorophore that can be excited by the 405 nm Violet laser and captured with a 510/50 nm bandpass filter. Pacific Green has an excititaion peak at 411 nm and an emission peak at 510 nm.

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