Villin 1 / Biotin / rVIL1/1325

Product Details

Description	This antibody recognizes a protein of 95kDa, which is identified as Villin 1. It is a major constituent in the microvilli, which compose the brush border of epithelial cells forming absorptive surfaces of the intestinal and renal proximal tubular epithelia. Anti-Villin 1 labels the brush border area in the gastrointestinal mucosal epithelium and urogenital tract. Among neoplasms, villin is predominantly expressed in tumors of colorectal origin. This antibody is useful in identifying malignant cells from primary and metastatic colorectal carcinomas; it also labels Merkel cells of the skin.
Conjugate	Biotin
Clone	rVIL1/1325
Target Species	Human
Applications	IHC-P, IHC
Supplier	Novus Biologicals
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About Villin 1
This gene encodes a member of a family of calcium-regulated actin-binding proteins. This protein represents a dominant part of the brush border cytoskeleton which functions in the capping, severing, and bundling of actin filaments. Two mRNAs of 2.7 kb and 3.5 kb have been observed; they result from utilization of alternate poly-adenylation signals present in the terminal exon. [provided by RefSeq, Jul 2008]

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