Bcl-2 / HRP / BCL2/2210R

Product Details

Description	This antibody recognizes a protein of 25-26kDa, identified as the bcl-2 oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Conjugate	HRP
Clone	BCL2/2210R
Target Species	Human
Applications	IHC-P, WB, IHC
Supplier	Novus Biologicals
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About Bcl-2
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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