POU2AF1 / Alexa Fluor 750 / BOB1/2425

Product Details

Description	BOB1 expression in a variety of established B-cell lines, representing different stages of B-cell development, has suggested a constitutive, B-cell-specific expression pattern. LP cells in nodular lymphocyte predominant Hodgkin lymphoma, because they are germinal center-derived, are consistently immuno-positive for BOB1. Conversely, only some cases of classical Hodgkin lymphoma show BOB1 immuno-reactivity within the Hodgkin and Reed-Sternberg cells. Expression of BOB1 has been reported in follicular center cell lymphoma, diffuse large B-cell lymphoma and some cases of acute myeloid leukemia. B-CLL, marginal zone lymphoma, and mantle cell lymphoma may show weak to moderate immunoreactivity.
Conjugate	Alexa Fluor 750
Clone	BOB1/2425
Target Species	Human
Applications	IHC-P, WB, IHC
Supplier	Novus Biologicals
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About POU2AF1
Enables transcription coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Part of RNA polymerase II transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

About Alexa Fluor 750
Alexa Fluor™ 750 (AF750, Alexa 750) has an excitation peak at 749 nm and an emission peak at 775 nm, and is spetrally similar to Cy®7 (GE Healthcare), APC-Fire™ 750 (BioLegend), CF®®750 (Biotium), DyLight™ 750 (ThermoFisher Scientific), iFluor® 750 (ATT Bioquest) and iFluor® 790 (ATT Bioquest). Alexa 750 is often used as a tandem fluorophore in flow cytometry or used on its own in fluorescence microscopy, in-vivo fluorescence microscopy or super-resolution microscopy applications.

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