PHD2 / Unconjugated / 2445D
Product Details
| Description | Human/Mouse EGLN1/PHD2 Antibody | |
|---|---|---|
| Conjugate | Unconjugated | |
| Clone | 2445D | |
| Target Species | Human, Mouse | |
| Applications | WB, IHC | |
| Supplier | R&D Systems | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About PHD2
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq, Nov 2009]
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247 PHD2 antibodies from over 12 suppliers available with over 35 conjugates.
