GPR56 / PE / REA467
Product Details
| Description | Clone REA467 recognizes the human G-protein coupled receptor 56 (GPR56) antigen, a multi-pass membrane protein, which is also known as TM7XN1. GPR56 is a member of the adhesion-GPCR family of receptors, which are characterized by an extended extracellular region with a variable number of protein domains coupled to a TM7 domain via a domain known as the GPCR-autoproteolysis inducing (GAIN) domain. It is expressed in a wide range of tissues, such as brain, thyroid gland, and heart. GPR56 has been shown to have numerous roles in cell guidance/adhesion as exemplified by its roles in tumor inhibition and neuron development. It is a receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basemant membrane integrity and in cortical lamination. Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12. More recently it has been shown to be a marker for cytotoxic T cells and a subgroup of natural killer cells. In melanocytic cells GPR56 gene expression may be regulated by MITF. | Additional information: Clone REA467 displays negligible binding to Fc receptors. | |
|---|---|---|
| Conjugate | PE | |
| Clone | REA467 | |
| Target Species | Human | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
| Size | ||
| Price | ||
| Antigen | ||
| Host | ||
| Isotype |
About GPR56
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Experiment Design Tools
Panel Builders
Looking to design a Microscopy or Flow Cytometry experiment?
Validation References
| PMID 21724806 | |
|---|---|
| PMID 10049584 | |
| PMID 22515446 | |
| Additional Sources |
|
Reviews & Ratings
| Reviews |
|---|
Looking for more options?
282 GPR56 antibodies from over 19 suppliers available with over 67 conjugates.
