CD278 / APC / 7E.17G9

Product Details

Description	Clone 7E.17G9 reacts with CD278, the inducible co-stimulatory molecule (ICOS), a 47–57 kDa homodimeric glycoprotein of the CD28 family. Directly ex vivo, CD278 is expressed only by a small subset of T cells, including follicular B helper T cells (TFH) and regulatory T cells. However, CD278 is strongly up-regulated on the surface following T cell activation. Upon binding to its ligand (ICOSL), CD278 initiates a multitude of events, which modulate many different aspects of T cell–mediated immune responses. Besides regulating differentiation and activation of effector as well as regulatory CD4+ T cells, ICOS also plays a role in germinal center formation and isotype switching.
Conjugate	APC
Clone	7E.17G9
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD278
The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]

About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

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