MSH2 / Unconjugated /
Product Details
| Description | Monoclonal Mouse Anti-Human MutS Protein Homolog 2, Clone FE11, Concentrated Antibody for Manual Use, Unconjugated, Ascites, protein A purified, Immunohistochemistry, 1 mL. MutS protein homolog 2 (MSH2) is part of the mismatch repair (MMR) pathway which is utilized by normal proliferating cells to repair mutations that may occur during DNA replication. Antibodies to MSH2 are a useful aid for classification of tumors of the gastrointestinal tract, including associated extracolonic cancers. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
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| Supplier | DAKO | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About MSH2
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
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