CD4 / Unconjugated /
Product Details
| Description | Monoclonal Mouse Anti-Human CD4, Clone 4B12, Concentrated Antibody for Manual Use, Unconjugated, Culture supernatant, Immunohistochemistry, 0.2 mL. CD4 is a transmembrane glycoprotein, expressed on normal thymocytes, T-helper cells, majority of mature peripheral T cells, and a subset of suppressor or cytotoxic T cells. CD4 is not found on immature thymocytes. The antibody is a useful aid for classification of anaplastic large cell lymphomas, unspecified peripheral T-cell lymphomas and mycosis fungoides. | |
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| Conjugate | Unconjugated | |
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| Target Species | Human | |
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| Supplier | DAKO | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD4
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]
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