Insulin / DyLight 650 / 2D11-H5

Product Details
Description Insulin is a protein consisting of an alpha-chain of 21 amino acids and a beta-chain of 30 amino acids and produced in the beta-cells of the pancreas. 2D11-H5 is a specific insulin mAb as tested by ELISA and on human pancreatic tissue. Source: A BALB/c mouse was immunised with swine insulin. The mouse spleen cells were fused with SP2/0 Ag14 cells and the clones were selected on anti-insulin activity.
Conjugate DyLight 650
Clone 2D11-H5
Target Species Human, Mouse
Applications ELISA, FC, ICC, IF, IHC-P, WB, IHC-Fr, IHC
Supplier Novus Biologicals
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About Insulin
This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified, including insulin-dependent diabetes mellitus, permanent neonatal diabetes diabetes mellitus, maturity-onset diabetes of the young type 10 and hyperproinsulinemia. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. [provided by RefSeq, May 2020]
About DyLight 650
DyLight™ 650 is a red-emitting fluorophore that excited by the 640 nm laser and collected using a 670/30 nm bandpass filter. DyLight™ 650 has an excitation peak at 652 nm and an emission peak at 672 nm, and is spectrally similar to Alexa Fluor™ 647 and Cy5. DyLight™ 650 is most commonly used in flow cytometery and fluorescence microscopy applications.
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