ErbB2 / CoraLite 594 / 1B12A7
Product Details
Description | The HER2/ErbB2 antibody from Proteintech is a mouse monoclonal antibody to a recombinant protein of human HER2/ErbB2. This antibody recognizes human antigen. The HER2/ErbB2 antibody has been validated for the following applications: IF, ELISA analysis. This antibody is coralite594-conjugated. | |
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Conjugate | CoraLite 594 | |
Clone | 1B12A7 | |
Target Species | Human | |
Applications | ELISA, IF | |
Supplier | Proteintech | |
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About ErbB2
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]
About CoraLite 594
CoraLite 594 from Proteintech has an excitation peak at 594 nm and an emission peak at 615 nm. It is spectrally similar to Alexa Fluorâ„¢ 594, ATTO594 and DyLightâ„¢ 594 and can be useful in fluorescence microscopy.
CoraLite 594 from Proteintech has an excitation peak at 594 nm and an emission peak at 615 nm. It is spectrally similar to Alexa Fluorâ„¢ 594, ATTO594 and DyLightâ„¢ 594 and can be useful in fluorescence microscopy.
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