CD274 / PE / REA1197

Product Details

Description	Clone REA1197 recognizes the human CD274 antigen, also known as programmed cell death 1 ligand 1 (PD-L1), an immune inhibitory receptor ligand which is involved in the costimulatory signal, essential for T cell proliferation and production of interleukin 10 (IL-10) and interferon gamma (IFN-gamma). \| CD274 is expressed on activated T cells, B cells, dendritic cells (DCs), antigen-presenting cells, keratinocytes, monocytes, and various types of tumor cells. In tissues, CD274 is highly expressed in the heart, skeletal muscle, placenta, and lung and weakly expressed in the thymus, spleen, kidney, and liver. \| PD-L1 is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. \| Additional information: Clone REA1197 displays negligible binding to Fc receptors.
Conjugate	PE
Clone	REA1197
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.

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