CD266 / APC-Vio770 / REA1216

Product Details

Description	Clone REA1216 recognizes CD266, also known as FN14, tumor necrosis factor receptor superfamily member 12A (TNFRSF12A), or tweak-receptor (TWEAKR). CD266 is a 14 kDa type I transmembrane glycoprotein belonging to the tumor necrosis factor (TNF) receptor superfamily and binds to TWEAK, a proinflammatory cytokine, as its only known ligand. The cytoplasmic tail of CD266 contains a TRAF binding motif and binds to TRAF1, TRAF2, TRAF3, and TRAF5. Both TWEAK dependent and independent CD266 signaling lead to activation of the NF-kappaB pathway. TWEAK independent signaling is shown when CD266 is ectopically overexpressed in vitro. Expression of CD266 is found on a wide variety of cells except for primary T and B cells. Elevated expression is often found in response to several growth factors, cytokines, hormones, after tissue injury, and in solid tumors such as glioblastoma multiforme tumors. Varied functions of TWEAK signaling include promotion of wound healing and regeneration, to influence the transition from innate to adaptive immunity and regulation of cell death and tumor progression. \| Additional information: Clone REA1216 displays negligible binding to Fc receptors.
Conjugate	APC-Vio770
Clone	REA1216
Target Species	Human, Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD266
Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

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