CD20 / PE / REA294

Product Details
Description Clone REA294 recognizes the murine CD20 antigen, a 32kDa membrane protein also known as B-cell differentiation antigen Ly-44. CD20 is a B lymphocyte-specific cell-surface molecule involved in the regulation of B-cell activation and proliferation. CD20 is expressed on B cells and a subset of T cells, but not on plasma cells. | Additional information: Clone REA294 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA294
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About CD20
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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