CD172a / APC-Vio770 / REA144

Product Details
Description Clone REA144 recognizes CD172a, which is also known as signal regulatory protein alpha (SIRPalpha). CD172a belongs to the Ig superfamily and is 75–110 kDa single-pass type I regulatory membrane protein. Expression of CD172a is found primarily on hematopoietic stem cells, neurons, and myeloid cells such as macrophages, monocytes, dendritic cells, granulocytes, and myeloid progenitors. CD172a phosphorylated at intracellular tyrosine sites, in response to extracellular stimuli, serves as the docking site for phosphatases such as SHP-1, SHP-2, or SHIP, which inturn desphosphorylate molecules involved in regulating various physiological effects. CD47 has been suggested as a ligand of CD172a. | Additional information: Clone REA144 displays negligible binding to Fc receptors.
Conjugate APC-Vio770
Clone REA144
Target Species Human
Applications FC
Supplier Miltenyi Biotec
Catalog # Sign in to view product details, citations, and spectra
Size
Price
Antigen
Host
Isotype
About CD172a
The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]
About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
Experiment Design Tools
Panel Builders

Looking to design a Microscopy or Flow Cytometry experiment?

Validation References
Reviews & Ratings
Looking for more options?

889 CD172a antibodies from over 33 suppliers available with over 77 conjugates.

Supplier Page
 Compare