CD162 / VioBlue / REA319
Product Details
| Description | Clone REA319 recognizes the human CD162 antigen, a single-pass type I membrane protein which is also known as P-selectin glycoprotein ligand 1 (PSGL-1). CD162 is expressed on neutrophils, monocytes, and most lymphocytes. It is the high affinity receptor for CD62P (P-selectin) on myeloid cells and stimulated T lymphocytes and mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. CD162 is also involved in homeostasis including stem cell homing to the thymus and mature T cell homing to secondary lymphoid organs. It has been found to bind the homeostatic chemokines CCL19 and CCL21 and to support the chemotactic response to these chemokines. | Additional information: Clone REA319 displays negligible binding to Fc receptors. | | | |
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| Conjugate | VioBlue | |
| Clone | REA319 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About CD162
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]
About VioBlue
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
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Validation References
| PMID 10770806 | |
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| PMID 7505206 | |
| PMID 19594630 | |
| PMID 26785849 | |
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