c-REL / PE / REA397

Product Details

Description	Clone REA397 recognizes the mouse c-Rel antigen, a 65 kDa member of the NF-kappaB family of eukaryotic transcription factors, which also includes the proteins RelA (p65), RelB, NF-kappaB1 (p105/p50), and NF-kappaB2 (p100/p52). NF-kappaB transcription factors can form various homo- and heterodimers possessing unique specificities in regulating target gene expression. While RelA-containing dimers are present in most cell types, c-Rel complexes are predominately found in cells of hematopoietic origin. In T cell lymphocytes, certain genes essential for immune function such as interleukin 2 (IL-2) and FoxP3 are directly regulated by c-Rel. Additionally, c-Rel-dependent IL-12 and IL-23 transcription by macrophages and dendritic cells (DCs) is crucial for T cell differentiation and effector functions. Accordingly, c-Rel expression in T cells and antigen-presenting cells controls a delicate balance between tolerance and immunity. \| Additional information: Clone REA397 displays negligible binding to Fc receptors.
Conjugate	PE
Clone	REA397
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About c-REL
This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.

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