CD45RA / APC-Cy7 / PTPRC/818

Product Details

Description	Recognizes a protein of 205kDa-220kDa, identified as CD45RA. CD45RA is isoforms of the human leukocyte common antigen (CD45). Human CD45 contains three exons which encode peptide segments designated A, B and C, respectively. The differential splicing of the exons generates at least five isoforms, ABC, AB, BC, B and O. This antibody reacts with ABC and BC isoforms. CD45RA is expressed on 40-50% of peripheral CD4+ T-cells, 50% of peripheral CD8+ T-cells, B-cells, and leukemic B-cell lines. T-cells expressing CD45RA are naive or virgin T-cells. T-cells expressing CD45RO are memory T-cells. CD45RA and CD45RO define complementary, predominantly non-overlapping populations of resting peripheral T-cells. This MAb is useful in study on the subpopulation of CD4+ or CD8+ T-cells. It can especially be used to differentiate T-cell lymphomas (CD45RO +ve) from B cell lymphomas (CD45RA +ve).
Conjugate	APC-Cy7
Clone	PTPRC/818
Target Species	Human
Applications	FC
Supplier	Novus Biologicals
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About APC-Cy7
APC-Cy7 (APC-Cyanine 7) has an excitation peak at 650 nm and an emission peak at 785 nm, and is spectrally similar to APC-CF®750 (Biotium), APC-H7 (BD Biosciences), APC-eFluor™ 780 (Thermo Fisher Scientific), APC-Vio®770 (Miltenyi Biotec) and APC-Fire™ 750 (BioLegend). This dye is a member of the Cyanine® dye family, a trademark of GE heathcare.

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