Collagen IV alpha 1 / DyLight 405 / 1043

Product Details
Description 1043 recognizes type IV collagen in the extracellular - basement membranes of normal and pathological human tissues.
Conjugate DyLight 405
Clone 1043
Target Species Human
Applications FC, ICC, IF, IHC-P, WB, IHC-Fr, IHC
Supplier Novus Biologicals
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About Collagen IV alpha 1
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
About DyLight 405
DyLight™ 405 has an excitation peak at 400 nm and an emission peak at 420 nm and is spectrally similar to Alexa Fluor™ 405 and Cascade Blue. DyLight™ 405 is most commonly used in flow cytometery and fluorescence microscopy applications.
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223 Collagen IV alpha 1 antibodies from over 15 suppliers available with over 37 conjugates.

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