53BP1 / PE /

Product Details
Description Rabbit 53BP1 antibody reacts with Human, Mouse, Rat, Bat, Bovine, Canine, Fish, Goat, Primate [PE]
Conjugate PE
Clone
Target Species Bat, Bovine, Canine, Fish, Goat, Human, Mouse, Primate, Rat
Applications KD, FC, Knockout Validated
Supplier Novus Biologicals
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About 53BP1
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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535 53BP1 antibodies from over 24 suppliers available with over 45 conjugates.

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