NRAS / Biotin /
Product Details
| Description | NRAS / N-ras Antibody (aa91-140, Biotin) | |
|---|---|---|
| Conjugate | Biotin | |
| Clone | ||
| Target Species | Bat, Bovine, Chimpanzee, Equine, Gibbon, Guinea Pig, Human, Monkey, Mouse, Orangutan, Porcine, Rabbit, Rat, Zebrafish | |
| Applications | IHC-P, WB, IHC | |
| Supplier | LifeSpan | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About NRAS
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
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