ITPR2 / Unconjugated /

Product Details
Description ITPR2 / IP3 Receptor Type 2 Antibody
Conjugate Unconjugated
Clone
Target Species Hamster, Human, Mouse, Orangutan, Rat
Applications IF, ICC, IHC-Fr, IHC
Supplier LifeSpan
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About ITPR2
The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
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76 ITPR2 antibodies from over 11 suppliers available with over 9 conjugates.

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