CD117 / APC-H7 / 2B8

Product Details
Description APC-H7 Rat anti-Mouse CD117
Conjugate APC-H7
Clone 2B8
Target Species Mouse
Applications FC
Supplier BD Biosciences
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About CD117
This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020]
About APC-H7
APC-H7 from BD Biosciences has an excitation peak at 651 nm and an emission peak at 785 nm. It's useful in flow cytometry and is spectrally similar to APC-Alexa 750, APC-CF®770, APC-Cy7, APC-Fire™ 750, APC-Vio®770, APC-eFluor™ 780 and Seta-APC-780.
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