DUX4 / Streptavidin / P2B1

Product Details
Description DUX4 Antibody (C-Terminus, clone P2B1, SA)
Conjugate Streptavidin
Clone P2B1
Target Species Human
Applications IF, IHC-P, WB, IHC
Supplier LifeSpan
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About DUX4
This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length; a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. The encoded protein has been reported to function as a transcriptional activator of paired-like homeodomain transcription factor 1 (PITX1; GeneID 5307). Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
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