IL-12/IL-23 (p40) / eFluor 450 / eBioHP40 (HP40, HP-40)
Product Details
Description | IL-12/IL-23 p40 Monoclonal Antibody (eBioHP40 (HP40, HP-40)), eFluor 450, eBioscienceâ„¢ | |
---|---|---|
Conjugate | eFluor 450 | |
Clone | eBioHP40 (HP40, HP-40) | |
Target Species | Human | |
Applications | FC | |
Supplier | Thermo Fisher Scientific | |
Catalog # | Sign in to view product details, citations, and spectra | |
Size | ||
Price | ||
Antigen | ||
Host | ||
Isotype |
About IL-12/IL-23 (p40)
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]
About eFluor 450
eFluorâ„¢ 450 (eF450) from Thermo Fisher Scientific has an excitation peak at 405 nm and an emission peak at 450 nm. It is useful in both flow cytometry and fluorescence microscopy.
eFluorâ„¢ 450 (eF450) from Thermo Fisher Scientific has an excitation peak at 405 nm and an emission peak at 450 nm. It is useful in both flow cytometry and fluorescence microscopy.
Experiment Design Tools
Panel Builders
Looking to design a Microscopy or Flow Cytometry experiment?
Validation References
Reviews & Ratings
Reviews |
---|
Looking for more options?
733 IL-12/IL-23 (p40) antibodies from over 21 suppliers available with over 45 conjugates.