ABCB5 / Unconjugated / C6-H3

Product Details

Description	ATP-binding cassette (ABC) transporters are an evolutionarily conserved family of proteins that catalyze the transport of molecules across extracellular and intracellular membranes by harnessing the energy of ATP hydrolysis. ABCB5 (ATP-binding cassette sub-family B member 5), also known as P-glycoprotein ABCB5 or ABCB5 P-gp, is a 812 amino acid multi-pass membrane protein that belongs to the superfamily of ABC transporters. Expressed ubiquitously, ABCB5 contains two ABC transporter domains and one ABC transmembrane type-1 domain and is responsible for the resistance to doxorubicin of a subset of malignant melanomas. It is suggested ABCB5 inhibits tumor growth and is thought to be a novel drug transporter and chemoresistance mediator in melanoma cells. Two isoforms of ABCB5, designated alpha and beta, exist due to alternative splicing events.
Conjugate	Unconjugated
Clone	C6-H3
Target Species	Human
Applications	FC, ICC, WB, IHC
Supplier	HuaBio
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About ABCB5
ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008]

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