PIWIL4 / Unconjugated / B11-G9

Product Details

Description	PIWIL4 (PIWI-like protein 4), also known as HIWI2 is a 852 amino acid protein that belongs to the argonaute family. PIWIL4 contains one PAZ domain and one PIWI domain and is essential for the maintenance of germline stem cells. PIWIL4 is a cytoplasmic protein that is expressed in adult testis. It regulates spermatogenesis and primordial germ cell production and has an essential role in meiotic differentiation of spermatocytes and in self-renewal of spermatogonial stem cells. PIWIL4-null mice are of normal size and weight and have the expected life span. Homozygous PIWIL4-null females are fertile and have no obvious defects. However, PIWIL4-deficient males are infertile and show a meiotic progression defect in early prophase of meiosis I and progressive loss of germ cells with age. Mutant males show elevated expression of LINE-1 and intracisternal A particle (IAP) element transcripts in germ cell lineages. The gene encoding PIWIL4 maps to human chromosome 11.
Conjugate	Unconjugated
Clone	B11-G9
Target Species	Human
Applications	FC, WB, IHC
Supplier	HuaBio
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About PIWIL4
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008]

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