Acrp30 / Unconjugated / D5-A12

Product Details

Description	Acrp30 (adipocyte complement-related protein or AdipoQ) is a secretory protein made exclusively in adipocytes with mRNA induced over 100-fold during adipocyte differentiation. Post-transcriptional modification of Acrp30 yields several oligomeric forms of varying molecular weight, including a monomer, a dimer, a trimer, a hexamer and a polymer. Acrp30 is an abundant serum protein, secreted exclusively from fat cells, and is implicated in energy homeostasis and obesity. Due to the dysregulation of Acrp30 in cases of obesity in humans and mice and the strong structural similarity to TNFα, Acrp30 is a suspected regulator of whole body energy homeostasis. In addition, regulated exocytosis of Acrp30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated Acrp30 secretion is blocked by pharmacologic inhibitors of this enzyme.
Conjugate	Unconjugated
Clone	D5-A12
Target Species	Human
Applications	FC, WB
Supplier	HuaBio
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About Acrp30
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]

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