SELENOS / Unconjugated / G1-F8
Product Details
| Description | Selenium is an essential trace element that is incorporated as selenocysteine into the primary structure of Selenoproteins. Nutritional deficiency of selenium decreases Selenoprotein concentrations and leads to pathologic conditions. Most of the known Selenoproteins are members of the glutathione peroxidase or iodothyronine deiodinase families. Selenoprotein S, also known as VIMP or SELS, is a 189 amino acid single-pass membrane protein that localizes to the endoplasmic reticulum (ER) and contains a selenocysteine (Sec) residue at its active site. Interacting with Derlin-1 and VCP, Selenoprotein S is involved in the degradation of misfolded ER proteins, specifically participating in the transfer of misfolded proteins from the ER to the cytosol for subsequent proteasomal degradation. Aberrant expression of Selenoprotein S is associated with diabetes, cardiovascular disease and rheumatoid arthritis. | |
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| Conjugate | Unconjugated | |
| Clone | G1-F8 | |
| Target Species | Human | |
| Applications | WB, IHC | |
| Supplier | HuaBio | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About SELENOS
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER). It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019). [provided by RefSeq, Jul 2017]
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