TNF beta / PE / REA1169

Product Details
Description Clone REA1169 recognizes the human TNF-beta antigen, a cytokine belonging to the tumor necrosis factors (TNF) family. TNF-beta is also known as lymphotoxin-a and is produced by activated lymphocytes, for example CD4+ and CD8+ T cells and some B lymphoblastoid cell lines. TNF-beta and TNF-alpha, which have similar biological activities and same receptors, are able to inhibit tumor growth. TNF-beta induces the synthesis of GM-CSF, G-CSF, interleukin 1 (IL-1), collagenase, and is a mitogen for B-lymphocytes. | Additional information: Clone REA1169 displays negligible binding to Fc receptors.
Conjugate PE
Clone REA1169
Target Species Human
Applications FC
Supplier Miltenyi Biotec
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About TNF beta
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkin's lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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