Ki-67 / Vio667 / REA183

Product Details

Description	Clone REA183 recognizes the Ki-67 antigen, a nuclear and nucleolar protein, which is strictly associated with cell proliferation. Two Ki-67 isoforms with molecular weight, 395 and 345 kDa are known. Both isoforms contain 16 “Ki-67 repeat“ sequences, each of which includes a conserved 66 bp “Ki-67 motif“. Expression of Ki-67 protein is present during all active phases of the cell cycle (G(1), S, G(2), and mitosis), but is absent from resting cells (G(0)). Due to strict association of Ki-67 with proliferating cells, Ki-67 is often used as an indicator of the “growth fraction“ of a given cell population. The N-terminal portion of Ki-67 contains a forkhead associated (FHA)1 domain, which is involved in interaction with proteins such as Hklp2 and NIFK. \| Additional information: Clone REA183 displays negligible binding to Fc receptors. \|
Conjugate	Vio667
Clone	REA183
Target Species	Human, Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About Ki-67
This gene encodes a nuclear protein that is associated with and may be necessary for cellular proliferation. Alternatively spliced transcript variants have been described. A related pseudogene exists on chromosome X. [provided by RefSeq, Mar 2009]

About Vio667
Vio® 667 from Miltenyi has an excitation peak at 635 nm and an emission peak at 668. It is spectrally comparable to Cy5 and Alexa Fluor™ 647.

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