Fc epsilon R1 alpha / VioBright 515 / REA1079
Product Details
| Description | Clone REA1079 recognizes the alpha subunit of the murine high-affinity Fc receptor for IgE. The receptor is composed of one alpha, one beta, and two disulfid-linked gamma subunits, of which the alpha subunit binds IgE1. FcepsilonRIalpha is expressed on mast and basophilic cells and is up-regulated in the presence of IgE. The FcepsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. | Additional information: Clone REA1079 displays negligible binding to Fc receptors. | |
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| Conjugate | VioBright 515 | |
| Clone | REA1079 | |
| Target Species | Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
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About Fc epsilon R1 alpha
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]
About VioBright 515
Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.
Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.
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Validation References
| PMID 2515952 | |
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| PMID 11431414 | |
| PMID 17982101 | |
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Reviews & Ratings
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