CD61 / PE-Vio615 / REA1192

Product Details

Description	Clone REA1192 recognizes a 110 kDa integrin beta chain known as CD61 or integrin beta3. Owing to multiple alpha/beta subunit combinations, integrins form an array of heterodimeric receptors, each recognising a multitude of ligands. CD61, in association with either alphav (CD51) or alphaIIb (CD41) integrin, binds to fibrinogen, fibronectin, von Willebrand factor, prothrombin, disintegrins, and thrombospondin. Due to binding to various extracellular matrix proteins and cellular receptors, integrins play a significant role in cell adhesion and cell movement. Furthermore, a pro-apoptotic function of CD61 has been suggested using a hepatocellular carcinoma (HCC) cell line and patient tissues. Expression of CD61 is found on platelets, B cell subsets, myeloid cells, mast cells, osteoclasts, endothelium, megakaryocytes, and smooth muscle cells. \| Additional information: Clone REA1192 displays negligible binding to Fc receptors.
Conjugate	PE-Vio615
Clone	REA1192
Target Species	Mouse, Rat
Applications	FC
Supplier	Miltenyi Biotec
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About CD61
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008]

About PE-Vio615
PE-Vio®615 from Miltenyi Biotec has an excitation peak at 565 nm and an emission peak at 619 nm. It is spectrally similar to PE-eFluor™ 610, PE-Dazzle 594 and PE-CF®594

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