VEGFR2 / PE / Avas12

Product Details
Description Clone Avas12 reacts with CD309, a receptor tyrosine kinase of the class 3 subfamily also known as vascular endothelial growth factor receptor 2 (VEGFR-2), kinase insert domain receptor (KDR), and fetal liver kinase-1 (flk-1). CD309 (VEGFR-2) is expressed on embryonic and adult endothelial cells and endothelial progenitor cells.
Conjugate PE
Clone Avas12
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About VEGFR2
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 9493833
PMID 12778165
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