CD164 / APC-Vio770 / 67D2
Product Details
| Description | Clone 67D2 recognizes the human CD164 antigen, a single-pass type I membrane protein, which is also known as sialomucin core protein 24, multi-glycosylated core protein 24 (MUC-24), or endolyn. CD164 is expressed by subpopulations of CD34+ cells. These include the majority of clonogenic myeloid and erythroid progenitors and the hierarchically more primitive precursors. Biochemical and functional characterization of CD164 indicate that this protein exists as a homodimeric molecule of approximately 160 kDa that participates in the adhesion of CD34+ cells to bone marrow stroma and functions as a signaling molecule, inhibiting the recruitment of primitive hematopoietic cells into cell cycle. CD164 may also play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. | |
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| Conjugate | APC-Vio770 | |
| Clone | 67D2 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD164
This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]
About APC-Vio770
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.
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Validation References
| PMID 9763543 | |
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| PMID 17077324 | |
| PMID 24094005 | |
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