T-bet / APC / REA102
Product Details
| Description | The monoclonal antibody REA102 recognizes human and mouse T-bet, a Tʜ1-specific T-box 1 transcription factor. T-bet is considered to be an important regulator of Tʜ1 lymphoid development and is involved in class-switch recombination in B cells. It is widely expressed in hematopoietic cells such as B cells, T cell subsets, NK and NKT cells, and dendritic cells. Expression of T-bet is induced by Tʜ1 cytokine IFN-gamma and T-bet further regulates the expression of cytokines including IFN-gamma, IL-12Rbeta, and IL-2. | Additional information: Clone REA102 displays negligible binding to Fc receptors. | | |
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| Conjugate | APC | |
| Clone | REA102 | |
| Target Species | Human, Mouse | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About T-bet
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 11786644 | |
|---|---|
| PMID 12802010 | |
| PMID 11960012 | |
| PMID 10761931 | |
| PMID 24763671 | |
| Additional Sources |
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