O4 / PE / REA576
Product Details
Description | Clone REA576 recognizes the human, mouse, and rat O4 antigen, a marker for oligodendrocytes, which are a type of glial cells. Their function is to provide a supporting role for neurons. During oligodendrocyte development, late A2B5+ oligodendrocyte progenitors start to express O4. As the cells differentiate, A2B5 expression ceases, whereas O4 expression persists. More mature cells start to synthesize galactocerebroside, MBP, PLP, MOG, and O1. O4 expression is found on Schwann cells in the peripheral nervous system. | Additional information: Clone REA576 displays negligible binding to Fc receptors. | |
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Conjugate | PE | |
Clone | REA576 | |
Target Species | Human, Mouse, Rat | |
Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
Supplier | Miltenyi Biotec | |
Catalog # | Sign in to view product details, citations, and spectra | |
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About PE
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts.
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Validation References
PMID 2600978 | |
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PMID 6786942 | |
PMID 11715061 | |
Additional Sources |
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13 O4 antibodies available with over 5 conjugates.