CD6 / PE-Vio770 / REA1075

Product Details
Description Clone REA1075 recognizes the human CD6 antigen, a 100 kDa transmembrane glycoprotein. CD6 is expressed on the majority of T cells as well as on a subset of B cells in peripheral blood. The CD6 antigen is also expressed at low levels on immature thymocytes and at high levels on mature thymocytes. CD6 functions as an adhesion molecule as well as costimulatory molecule for TCR-mediated T cell activation. | Additional information: Clone REA1075 displays negligible binding to Fc receptors.
Conjugate PE-Vio770
Clone REA1075
Target Species Human
Applications FC
Supplier Miltenyi Biotec
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About CD6
This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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Validation References
PMID 7760007
PMID 15048703
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