CD49d / VioBright 515 / REA807

Product Details

Description	Clone REA807 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin alpha4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1). \| Additional information: Clone REA807 displays negligible binding to Fc receptors.
Conjugate	VioBright 515
Clone	REA807
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD49d
The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 4 subunit. This subunit associates with a beta 1 or beta 7 subunit to form an integrin that may play a role in cell motility and migration. This integrin is a therapeutic target for the treatment of multiple sclerosis, Crohn's disease and inflammatory bowel disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

About VioBright 515
Vio®Bright® B515 from Miltenyi has an excitation peak at 488 nm and an emission peak at 514. It is comparable to BB515 in flow cytometry.

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