CD352 / PE-Vio770 / REA1097

Product Details
Description Clone REA1097 recognizes the mouse CD352 antigen, a single-pass type I membrane protein also known as SLAM family member 6 (SLAM6), NK-, T-, and B-cell antigen (NTB-A) or Ly108 belonging to the CD2 subfamily of the immunoglobulin superfamily. It is expressed on NK, T, and B cells. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases. CD352 plays a role in NK cell cytotoxicity and T cell cytokine responses. It controls neutrophil functions and serves as a regulator of both innate and adaptive immune responses. | Additional information: Clone REA1097 displays negligible binding to Fc receptors.
Conjugate PE-Vio770
Clone REA1097
Target Species Mouse
Applications FC
Supplier Miltenyi Biotec
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About CD352
The protein encoded by this gene is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. This encoded protein is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It functions as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, May 2010]
About PE-Vio770
PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
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