VEGFR2 / APC / REA1046
Product Details
| Description | Clone REA1046 recognizes the CD309 antigen, a transmembrane tyrosine kinase, also known as vascular endothelial growth factor receptor-2 (VEGFR-2) or kinase insert domain–containing receptor (KDR). CD309 is a high-affinity receptor for VEGF and plays a role in hematopoiesis. It is also involved in angiogenesis, both during embryogenesis and in the context of homeostatic or pathological events, e.g., vascularization of tumors. It has been identified on a subset of hematopoietic stem cells (HSCs), endothelial progenitor cells (EPCs), as well as on their common progenitor, the hemangioblast. CD309 expression is also found on mature endothelial cells (ECs). | Additional information: Clone REA1046 displays negligible binding to Fc receptors. | |
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| Conjugate | APC | |
| Clone | REA1046 | |
| Target Species | Human | |
| Applications | FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About VEGFR2
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
Vascular endothelial growth factor (VEGF) is a major growth factor for endothelial cells. This gene encodes one of the two receptors of the VEGF. This receptor, known as kinase insert domain receptor, is a type III receptor tyrosine kinase. It functions as the main mediator of VEGF-induced endothelial proliferation, survival, migration, tubular morphogenesis and sprouting. The signalling and trafficking of this receptor are regulated by multiple factors, including Rab GTPase, P2Y purine nucleotide receptor, integrin alphaVbeta3, T-cell protein tyrosine phosphatase, etc.. Mutations of this gene are implicated in infantile capillary hemangiomas. [provided by RefSeq, May 2009]
About APC
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.
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Validation References
| PMID 7596435 | |
|---|---|
| PMID 7781909 | |
| PMID 8724693 | |
| PMID 9144204 | |
| Additional Sources |
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Reviews & Ratings
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