CD30 / VioBlue / REA1085
Product Details
| Description | Clone REA1085 recognizes the human CD30 antigen, a cell membrane protein, which is a member of the tumor necrosis factor receptor (TNFR) superfamily, and also known as Ki-1. CD30 is used as a tumor marker and is found on Hodgkin/Reed-Sternberg (H/RS) cells, embryonal carcinoma cells, and on activated T and B lymphocytes. It functions as a receptor for TNFSF8/CD30L and is involved in the regulation of cellular growth and transformation of activated lymphoblasts and regulates signal transduction by activation of NF-kappaB. | Additional information: Clone REA1085 displays negligible binding to Fc receptors. | |
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| Conjugate | VioBlue | |
| Clone | REA1085 | |
| Target Species | Human | |
| Applications | FC | |
| Supplier | Miltenyi Biotec | |
| Catalog # | Sign in to view product details, citations, and spectra | |
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About CD30
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
About VioBlue
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
Vio®Blue® has an excitation peak at 400 nm and an emission peak at 455 nm, and is spectrally similar to eFluor™ 450 (ThermoFisher Scientific), V450 (BD Biosciences), Alexa Fluor™ 405 (ThermoFisher), Pacific Blue (ThermoFisher Scientific) and ATTO 425 (AttoTec).
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Validation References
| PMID 8627180 | |
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| PMID 8999898 | |
| PMID 11901204 | |
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