CD200 / Biotin / REA1067

Product Details

Description	Clone REA1067 recognizes the human CD200 antigen, also known as MRC, MOX1/2, or OX-2, a type 1 membrane glycoprotein, which contains two immunoglobulin domains. Studies of the related gene in mouse and rat suggest that CD200 may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. CD200 may serve as a cancer stem cell marker as co-expression with other reported stem cell markers was found on prostate, breast, brain, and colon cancers. In addition, CD200 expression was shown to be a prognostic factor in AML and multiple myeloma. \| Additional information: Clone REA1067 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA1067
Target Species	Human
Applications	FC
Supplier	Miltenyi Biotec
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About CD200
This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

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