CD30L / Biotin / REA1083

Product Details

Description	Clone REA1083 recognizes the mouse CD153 (CD30 ligand) antigen, a 40 kDa type II membrane protein belonging to the NGF/TNF superfamily. It is expressed by activated CD4+ and CD8+ T cells. The interaction between CD30 and CD153 enhance the proliferation of stimulated T cells but in the presence of the REA1083 antibody this effect is blocked. In vivo treatment with this antibody is reported to inhibit or delay immune reactions. \| Additional information: Clone REA1083 displays negligible binding to Fc receptors.
Conjugate	Biotin
Clone	REA1083
Target Species	Mouse
Applications	FC
Supplier	Miltenyi Biotec
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About CD30L
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

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