CD20 / Unconjugated / MEM-269

Product Details

Description	CD20 is also called L26 or membrane spanning 4 domains (MS4A1). It is a 33 kd phosphoprotein with 3 hydrophobic regions that traverse the cell membrane, creating a structure similar to an ion channel that allows for the influx of calcium ions required for cell activation. Initially expressed on B cells after CD19/CD10 expression and before CD21/CD22 and surface immunoglobulin expression. It is retained on mature B cells until plasma cell development.
Conjugate	Unconjugated
Clone	MEM-269
Target Species	Human
Applications	FC, IHC-P
Supplier	Aviva Systems Biology
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About CD20
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. [provided by RefSeq, Jul 2008]

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